[on Anemia, with Special Reference to Megaloblastic Anemia].

It was confirmed by fecal excretion test and Schilling's urinary excretion test using vitamin B@12 labelled with @60Co (@60Co-B@12) that the intestinal absorption of vitamin B@12 was markedly disturbed in patients with pernicious anemia. When @60Co-B@12 was given by mouth together with hog intrinsic factor in patients with pernicious anemia, the intestinal absorption of @60Co-B@12 was restored to normal. It was also shown that this vitamin B@12 absorption test using @60Co-B@12 was very useful for establishing the diagnosis of pernicious anemia in cases with subacute combined degeneration of the spinal cord even when there was no definite hematological manifestation of megalohlastic anemia.